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New data from hyponatremia treatment trials released

Published in Medical Letter on the CDC and FDA, December 5th, 2004

Yamanouchi Pharma America, Inc., a subsidiary of Yamanouchi Pharmaceutical Co., Ltd., announced that its investigational drug, conivaptan hydrochloride, produced significant increases in serum sodium levels in patients with hyponatremia.

Hyponatremia is a potentially life-threatening condition that occurs when the body's sodium level falls below normal. The results of two, phase III studies were presented this weekend at the annual meeting of the American Society of Nephrology.

Conivaptan is a novel drug that blocks both V1A and V2 vasopressin receptors, increasing serum sodium and urine output without increasing sodium loss. This effect, known as...

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