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Table of Contents . . . December 12th, 2004
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Medical Letter on the CDC & FDA | Other Publications
Anthrax Vaccine - Mass value for IgG in standard anthrax reference serum assigned
Cancer Vaccine - IL-13 antagonist and Pseudomonas toxin fusion protein is anticancer
Ebola Virus - Disulfide bonds of Ebola-virus-secreted glycoprotein SGP assigned
Enzyme Immunoassays - Enzyme immunoassay tests to detect Mycoplasma antibodies assessed
Salmonella Vaccine - Live Salmonella vaccine protects against Salmonella enteritidis
AIDS/HIV Pathogenesis - CD4+ T cell depletion in HIV occurs predominantly in gastrointestinal tract
AIDS/HIV Pathogenesis - HIV linked to depletion of CD4+ T cells from effector sites in GI tract
AIDS/HIV Vaccine - Novel and promiscuous CTL epitopes in conserved regions of Gag identified
AIDS/HIV Vaccine - Therapeutic HIV vaccines reviewed
AIDS/HIV Vaccine - Vaccine provides T-cell-mediated protection in monkeys after SIV challenge
Addiction Medicine - Company licenses oral drug to treat impulse control disorder
Adverse Drug Effects - Dinitrophenol-related fatality reported
Adverse Drug Effects - Long-term use of depo-provera contraceptive injection may cause osteoporosis
Alcohol Abuse - Changes in cannabinoid brain receptor play role in alcoholism relapse
Amino Acid Supplementation - Branched-chain amino acid supplementation does not alter performance in the heat
Amyotrophic Lateral Sclerosis - ALS drug candidate Myogane gets U.S. FDA Fast Track designation
Anesthesia - Consider the effect of anesthesia when measuring circulating blood elements
Angiology - Hypoxia and erythropoietin cause endothelial cells to generate nitric oxide
Anthrax - Company completes first phase of ThraxVax design
Asthma - Neighborhoods near heavily traveled border crossings have high asthma incidence
Bacteremia - Enrollment complete for Cubicin's phase III endocarditis/bacteremia trial
Bladder Cancer - Promising data presented on phase 2 trial drug for superficial bladder cancer
Business & Finance - Company reports Q3 results, provides MS-325 regulatory update
Business & Finance - Company reports third quarter results, Chrysalin product activities
Business & Finance - Developer of surgical and diagnostic products announces financial results
Business & Finance - Prochieve maker provides Q3 report, updates PROTERM study
Business Update - ComfortScan agreements inked in Canada, Italy, and Russia
Business Update - Molecular diagnostics company announces expansion of diagnostic pipeline
Cancer Therapy - VELCADE gets fast track status for relapsed and refractory mantle cell lymphoma
Cardiac Arrhythmias - Freezor MAX obtains FDA approval in the U.S.
Cardiology - Pharmaceutical company comments on results of coronary artery disease study
Cardiology - Study shows differences in cardiovascular risk among cox-2 inhibitors
Cholera Vaccine - Vibrio cholerae amino acid sequence induces protective antibodies
Chronic Obstructive Pulmonary Disease - COPD afflicts three times the number of adults than previously estimated
Colon Cancer - ELOXATIN approved for colon cancer treatment following surgery
Dengue Virus - Dengue viral infections reviewed
Disease Prevention - African leaders, health activists push for money to fight disease
Disease Prevention - Global health alert network now scans for disease reports in seven languages
Disease Prevention - Lack of reliable death tolls worldwide makes curing the sick even tougher
Drug Development - Autoradioluminography useful to find tritium-labeled drug candidates
Drug Development - Bristol-Myers expects to file two additional new drug applications by year end
Drug Development - Elderly cancer patients significantly underrepresented in cancer trials
Drug Development - Immunosuppressant to enter clinical trials
Drug Development - WHO develops priorities for drug research, including expected flu vaccines
Environmental Health - Updated government study finds mercury levels in women, children 'not a concern'
Environmental Toxins - Government group to develop new RNAi library to help fight disease
Finance - GR-system developer reports Q3 net loss of $6.7 million
Finance - Genetic analysis company reports 190% increase in product sales in Q3
Finance - Medical research company reports 14% increase in net sales during first quarter
Finance - Pharmaceutical company reports 3Q results, highlighted by launch of lead product
Finance - Transdermal drug delivery pharmaceutical reports third quarter EPS of $0.11
Finances - Bridge financing for phase 2 trial on blood substitute set, phase 3 funds sought
Food Safety - Lateral flow strip for the detection of mycotoxins in grain introduced
Genetics & Genomics - United Nations approves first international standard for human genetic test
HIV Treatment - Monoclonal antibody among HIV therapies discussed at human virology meeting
HIV/AIDS Care - Family home AIDS care in rural sub-Saharan Africa is a minimal burden
HIV/AIDS Care - Level of HIV/AIDS patient care better if health facility funded by CARE Act
HIV/AIDS Cost - Household costs attributable to AIDS in Chad are devastating
HIV/AIDS Economics - Expenditure more sensitive indicator of economic impact of HIV/AIDS than income
HIV/AIDS Epidemiology - Reduction in new HIV infections in Southeast Spain
HIV/AIDS Healthcare - HIV/AIDS patients in Malawi seek hospital healthcare as a last resort
HIV/AIDS Prevention - Gay sex workers play important role as sex educators on the Internet
HIV/AIDS Prevention - Russian government lacks will to combat spread of HIV/AIDS, experts say
HIV/AIDS Prevention - STD/HIV prevention website navigation tools not helpful enough for teenagers
HIV/AIDS Psychology - Internet is a viable recruitment tool for reaching HIV at-risk individuals
HIV/AIDS Risk - High-risk sexual behavior prevalent among drug users in Pakistan
HIV/AIDS Risk - Online choice for sex-seeking among gay males varies with education level
HIV/AIDS Testing - Many people in the U.K. do not need to access HIV test results in person
HIV/AIDS Vaccine - Role of gastrointestinal T cells in HIV pathogenesis reviewed
Healthcare & Politics - New institute looks at healthcare in the second Bush administration
Healthcare Coverage - Gaps in pharmaceutical research and innovation can be closed, says WHO report
Healthcare Coverage - U.S. veterans give VA top healthcare rating for 5 years in a row
Healthcare Financing - Diabetes among older adults imposed an estimated $133.5 billion cost in 1990s
Healthcare Management - Over-the-counter medications can provide financial benefits
Heart Disease - U.S. FDA allows qualified health claim regarding risk of coronary heart disease
Hemorrhagic Fever - Signal peptide of arenavirus glycoprotein forms mature G1-G2 complex subunit
Herpesvirus - Early expression of HSV-1 ICP27 transcript not critical for replication
Hypertension Epidemiology - Adult hypertension in United States on the increase
Influenza - NIAID launches influenza genome sequencing project
Influenza - WHO says flu vaccine coming within year
Influenza Vaccine - HHS head Thompson announces contract to support egg supply for flu vaccines
Injury Prevention - Hands-free cell phones dangerously distract drivers' attention
Ischemia - An NO-dependent mechanism mediates sex difference in [Na+ ]i regulation
Laboratory Methods - Study investigated methods of euthanasia for mouse fetuses and neonates
Leishmaniasis Vaccine - Leishmania major exogenous antigens protects against infection
Leishmaniasis Vaccine - Central memory T cells mediate long-term immunity to Leishmania major
Leishmaniasis Vaccine - T cells mediate immunity to Leishmania major in absence of parasites
Lipid Disorders - FDA grants approval for new formulation of TriCor
Liver Cancer Risk - Arsenic exposure increases the risk for liver cancer in females
Lumbar Spinal Stenosis - Spinal disorders-focused company receives U.S. FDA notice on for LSS device
Lyme Disease - Borrelia burgdorferi changes antigens based on host immune response
Lyme Disease - Receptor identified in tick guts
Malaria - Cytokine levels in Malian children with severe malaria determined
Malaria - Fine specificity of merozoite antibodies linked to malaria resistance
Malaria Vaccine - Plasmodium yoelii proteins enhance protection against malaria
Malaria Vaccine - Anatomy of Plasmodium falciparum MSP-1 epitope mapped
Malaria Vaccine - Antigenic drift in Plasmodium vivax protein confers antibody resistance
Malaria Vaccine - Immunogenicities of Plasmodium vivax protein fragments compared
Malaria Vaccine - Merozoite protein protects against lethal malaria parasite challenge
Measles Vaccine - Measles vaccination rate in developed world
Melanoma Vaccine - Quiescent phenotype of tumor-specific CD8+ T cells following immunization
Meningitis Epidemiology - Haemophilus influenzae incidence in South Korean children reported
Nephropathy - U.S FDA grants orphan drug designation for CR002 in IgA nephropathy indication
Neurology - Companies announce agreement for technology used in clinical trials of stroke treatment
Neuroscience - Novel syntaxin-1-binding protein identified
Nicotine Addiction - Grant to study why teens smoke
Nutrition - Dietary supplements manufacturer endorses dietary supplement act
Obstetrics - U.S. FDA adds new warnings to mifepristone labeling
Occupational Health - Occupational health and gorilla conservation in Rwanda
Oncogenesis - Nuclear factor-kappa B rules the malignant phenotype of squamous cell carcinoma
Oncology - Bevacizumab reduces tumor progression in patients with metastatic renal cancer
Oncology - Pharmaceutical company announces Phase I clinical trial for myeloma treatment
Oncology - Xcytrin data prsented at Chemotherapy Foundation Symposium XXII
Oral Health - The market for betel quid is increasing despite risk to oral health
Pain Medicine - Survey: Doctors cautiously supportive of COX-2 drugs in wake of Vioxx withdrawal
Parvovirus Therapy - Sequestration of receptor by NS2 mutations regulates parvovirus fitness
Patents - Anticancer drug receives Candian patent
Patents - Canada-based biotechnology company receives U.S. patent for vaccine production
Patents - Collagen Infusion Delivery System receives U.S. patent
Pediatric Cancer - U.S. NCI pediatric program established under contract to research hospital
Personnel - Clinical research company announces new regulatory affairs leader
Personnel - Martin Kaplan, U.N. scientist and former head of Pugwash, dies at 89
Plastic Surgery - Company announces clinical trial results for permanent injectable wrinkle filler
Pneumococcal Vaccine - Multiplex opsonophagocytosis assay useful to monitor pneumococcal vaccine
Pneumonia - IND submitted for aerosolized antibiotic
Policy - Poor communities should decide their own priorities for aid
Poliomyelitis - U.N. says African conflicts, funding gap threaten polio eradication
Primary Biliary Cirrhosis - URSO Forte launched in the U.S.
Product Licensing - Biotech company obtains patent for key target involved in chronic pain
Product Licensing - U.S. Patent issued for nucleic acid amplification device for biological research
Product Licensing - U.S. patent granted for technology to detect nucleic acid sequences
Quality of Life - New WHO study asks, "How happy are you with your lot in life?"
Regulatory Issues - Pharmacists share concerns about relaxation of drug importation laws
Renal Disease - Hepatitis C treatment receives new indication in Europe
Respiratory Syncytial Virus - Signaling via prostaglandin receptor protects against RSV
SARS Virus - Native form of recombinant SARS coronavirus spike glycoprotein characterized
Salmonella Vaccine - Attenuated Salmonella mutants cause fatal infections in mice
Schistosomiasis Vaccine - Vaccine protects against tetanus and schistosomiasis in mice
Skin Cancer - Learning to cover up reduces risk of skin cancer
Skin Cancer Marker - HLA A11 is marker for nonmelanomatous skin cancer risk after renal transplant
Smoking Cessation - HHS launches new initiatives to help Americans quit smoking
Sports Medicine - U.S. FDA clears technology designed to simplify common sports-related surgery
Substance Abuse - 2004 survey shows decline in teen drug use continues
Tardive Dyskinesia - Upswing in metoclopramide use linked with neurologic symptoms
Treatment - VNS maker reports Q2 results, makes sales targets
Tuberculosis - Cytokine responses and active TB disease in HIV-1-infected Ugandans studied
Tuberculosis - Pulmonary tuberculosis associated with diabetes
Tuberculosis - Tuberculosis and HIV co-infection is a symbiotic relationship
Tuberculosis Vaccine - BCG can subvert monocyte differentiation into dendritic cells
Tuberculosis Vaccine - CD8 T cell activation protects against pulmonary tuberculosis
Tuberculosis Vaccine - Guidelines for latent tuberculosis testing and treatment released
Tuberculosis Vaccine - Lipoarabinomannan antibody prolongs survival of mice with tuberculosis
Uterine Leiomyomas - U.S. FDA approves new device to treat uterine fibroids
Vaccine Development - U.S. HHS buys new anthrax vaccine for stockpile
Vaccinia Virus - Vaccinia virus mutants fail to initiate morphogenesis
Varicella-Zoster Virus - Epidemiology of severe varicella-zoster infection in Spain reported
Virology - Internal controls enhance the detection of waterborne enteric viruses
West Nile Virus - CDC expects mild season for mosquito-borne virus
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