SARS Virus
Native form of recombinant SARS coronavirus spike glycoprotein characterized
Published in Medical Letter on the CDC and FDA, December 12th, 2004
"We have expressed and characterized the severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein in cDNA-transfected mammalian cells. The full-length spike protein (S) was newly synthesized as an endoglycosidase H (endo H)-sensitive glycoprotein (gp170) that is further modified into an endo H-resistant glycoprotein (gp180) in the Golgi apparatus. No substantial proteolytic cleavage of S was observed, suggesting that, S is not processed into head (S1) and stalk (S2) domains as observed for certain other coronaviruses,"...
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