Tuberculosis Vaccine
BCG can subvert monocyte differentiation into dendritic cells
Published in Medical Letter on the CDC and FDA, December 12th, 2004
According to recent research from Italy, "The only available vaccine against tuberculosis (TB) is Bacillus Calmette-Guerin whose efficacy in preventing pulmonary tuberculosis is however controversial. Here, we show that BCG infection of monocytes causes their differentiation into mature dendritic cells (DCs) lacking CD I molecules expression, coupled with suboptimal up-regulation of HLA class 11, CD80 and CD40 molecules and a marked unresponsiveness to lipopolysaccharide stimulation."
"In...
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