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Alcohol Abuse
Changes in cannabinoid brain receptor play role in alcoholism relapse
December 12th, 2004
Changes in the cannabinoid brain receptor may play an important role in alcoholism relapse. "Alcoholism is characterized by successive relapses. Recent data have shown a cross-talk between the cannabinoid system and ethanol. In this study, male Wistar rats with a limited (30-minute sessions), intermittent, and extended background of alcohol operant self-administration were used. The relapse to alcohol after one week of alcohol deprivation was evaluated," investigators in Spain report. "Two weeks later, the animals were treated with the cannabinoid agonist WIN 55,212-2 (R-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo[1,2,3-de]-...
Source: Medical Letter on the CDC & FDA (2004-12-12)
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