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Angiology
Hypoxia and erythropoietin cause endothelial cells to generate nitric oxide
December 12th, 2004
Hypoxia and erythropoietin cause endothelial cells to generate nitric oxide. According to a study from the United States, "erythropoietin (EPO), a hypoxia-inducible cytokine, is required for survival, proliferation, and differentiation of erythroid progenitor cells. EPO can also stimulate proliferation and angiogenesis of endothelial cells that express EPO receptors (EPORs). In this study we investigated the EPO response of vascular endothelial cells at reduced oxygen tension (5% and 2%), in particular the effect of EPO on nitric oxide (NO) release." "Endothelial nitric oxide synthase (eNOS) produces NO, which maintains blood pressure homeostasis and...
Source: Medical Letter on the CDC & FDA (2004-12-12)
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