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Medical Letter on the CDC & FDA

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Anthrax Vaccine



Mass value for IgG in standard anthrax reference serum assigned



December 12th, 2004

Scientists have assigned the mass values for total and subclass immunoglobulin G in a human standard anthrax reference serum.

According to recent research published in the journal Clinical and Diagnostic Laboratory Immunology, "An anti-anthrax vaccine adsorbed (anti-AVA) standard human reference serum pool, AVR414, has been prepared, and the total and protective antigen (PA)-specific immunoglobulin G (IgG) were quantified. AVR414 was prepared by plasmapheresis of healthy adults who had received a minimum of four subcutaneous injections of AVA. Mass values (mg/mL) for total IgG and IgG subclasses 1 to 4 were determined by radial immunodiffusion."

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Source: Medical Letter on the CDC & FDA (2004-12-12)

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