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Cholera Vaccine
Vibrio cholerae amino acid sequence induces protective antibodies
December 12th, 2004
A Vibrio cholerae classical TcpA amino acid sequence induces protective antibody that binds an area hypothesized to be important for toxin-coregulated pilus structure. "Vibrio cholerae is a Gram-negative bacterium that has been associated with cholera pandemics since the early 1800s. Whole-cell, killed, and live-attenuated oral cholera vaccines are in use. We and others have focused on the development of a subunit cholera vaccine that features standardized epitopes from various V. cholerae macromolecules that are known to induce protective antibody responses," scientists writing in the journal Infection and Immunity report. ...
Source: Medical Letter on the CDC & FDA (2004-12-12)
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