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Cholera Vaccine

 Vibrio cholerae amino acid sequence induces protective antibodies

Published in Medical Letter on the CDC and FDA, December 12th, 2004

A Vibrio cholerae classical TcpA amino acid sequence induces protective antibody that binds an area hypothesized to be important for toxin-coregulated pilus structure.

"Vibrio cholerae is a Gram-negative bacterium that has been associated with cholera pandemics since the early 1800s. Whole-cell, killed, and live-attenuated oral cholera vaccines are in use. We and others have focused on the development of a subunit cholera vaccine that features standardized epitopes from various V. cholerae macromolecules that are known to induce protective antibody responses," scientists writing in the journal Infection and Immunity report.

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