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Ebola Virus
Disulfide bonds of Ebola-virus-secreted glycoprotein SGP assigned
December 12th, 2004
Scientists have assigned the disulfide bonds of the Ebola-virus-secreted glycoprotein SGP. "The non-structural glycoprotein (SGP) of Ebola virus (EboV) is secreted in large amounts from infected cells as a disulfide-linked homodimer. In this communication, highly purified SGP, derived from Vero E6 cultures infected with the Zaire species of EboV, was used to determine the correct localization of inter- and intrachain disulfide bonds. Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry analysis of proteolytic cleavage fragments indicates that all cysteines (six per monomeric unit) form unique disulfide bonds," scientists in the United States...
Source: Medical Letter on the CDC & FDA (2004-12-12)
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