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Drug Development
Autoradioluminography useful to find tritium-labeled drug candidates
December 12th, 2004
whole-body autoradioluminography is useful in drug discovery for the quantification of tritium-labeled drug candidates. According to a study from the United States, "Whole-body autoradioluminography (WBAL) has evolved as the preferred method for conducting tissue distribution studies that are required for regulatory filings of a new drug entity (DE) and for projecting tissue dosimetry in human mass balance studies. Four experiments were designed to assess WBAL utility using tritium as early as lead development in the drug discovery process. The objective of experiment 1 was to determine the minimum amount of tritium to administer to rats required for obtaining...
Source: Medical Letter on the CDC & FDA (2004-12-12)
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