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AIDS/HIV Pathogenesis
CD4+ T cell depletion in HIV occurs predominantly in gastrointestinal tract
December 12th, 2004
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. "The mechanisms underlying CD4+ T cell depletion in human immunodeficiency virus (HIV) infection are not well understood. Comparative studies of lymphoid tissues, where the vast majority of T cells reside, and peripheral blood can potentially illuminate the pathogenesis of HIV-associated disease. Here, we studied the effect of HIV infection on the activation and depletion of defined subsets of CD4+ and CD8+ T cells in the blood, gastrointestinal (GI) tract, and lymph node (LN)," scientists in the United States report. "We also measured...
Source: Medical Letter on the CDC & FDA (2004-12-12)
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