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AIDS/HIV Pathogenesis
HIV linked to depletion of CD4+ T cells from effector sites in GI tract
December 12th, 2004
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. According to a study from the United States and Germany, "Given its population of CCR5-expressing, immunologically activated CD4+ T cells, the gastrointestinal (GI) mucosa is uniquely susceptible to human immunodeficiency virus (HIV)-1 infection. We undertook this study to assess whether a preferential depletion of mucosal CID4+ T cells would be observed in HIV-1-infected subjects during the primary infection period, to examine the anatomic subcompartment from which these cells are depleted, and to examine whether suppressive highly...
Source: Medical Letter on the CDC & FDA (2004-12-12)
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