Malaria Vaccine

Immunogenicities of Plasmodium vivax protein fragments compared

Published in Medical Letter on the CDC and FDA, December 12th, 2004

Scientists compare immunogenicities of recombinant Plasmodium vivax merozoite surface protein 1 19- and 42-kilodalton fragments expressed in Escherichia coli in a recent issue of Infection and Immunity.

"The 42- and 19-kDa C-terminal fragments of merozoite surface protein 1 (MSP-1₄₂ and MSP-1₁₉ , respectively) are both promising blood-stage vaccine candidate antigens. At present, it is not clear which of the two antigens will be more suitable for inclusion in a cocktail malaria vaccine. In the present study, we expressed the two C-terminal fragments of Plasmodium vivax MSP-1 (PvMSP-1) in an Escherichia coli...

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Source: Medical Letter on the CDC and FDA (2004-12-12)

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