Rhabdomyolysis

Risk of muscle-damaging disorder low for most commonly prescribed statin drugs

Published in Medical Letter on the CDC and FDA, December 19th, 2004

Patients taking the lipid-lowering medications atorvastatin, pravastatin and simvastatin to reduce cholesterol levels have a relatively low risk of developing rhabdomyolysis, (a disorder that causes the breakdown of muscle), according to a new study.

However, older patients with diabetes mellitus taking combined statin-fibrate therapy appear to be at an increased risk for rhabdomyolysis. And patients who were taking cerivastatin combined with fibrates had a significantly higher risk of about 1 in 10 treated patients each year. Cerivastatin was removed from the U.S. market in 2001 because of high reporting of rhabdomyolysis in association with its use. The study,...

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Source: Medical Letter on the CDC and FDA (2004-12-19)

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