Smallpox

Computer modeling helps identify new smallpox drug candidate

Published in Medical Letter on the CDC and FDA, December 19th, 2004

Using bioinformatics and computer modeling, researchers from North Carolina and Oregon have identified a new class of compounds that block a key step in the lifecycle of the smallpox virus and have little toxicity to human cells.

They reported on this new antiviral drug candidate in the Journal of Virology.

An outbreak of the smallpox virus is considered to be one of the greatest threats facing the world today. No antiviral drug has proved effective against human smallpox. One antiviral currently available for treatment of orthopoxviruses offers some defense but must be administered intravenously and has a high risk of adverse side...

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Source: Medical Letter on the CDC and FDA (2004-12-19)

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