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Ebola Virus

Ebola amino acid motif required for interferon antagonism

Published in Medical Letter on the CDC and FDA, December 19th, 2004

A C-terminal basic amino acid motif of Zaire ebola virus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virus.

According to recent research published in the journal Virology, "The ebola virus VP35 protein antagonizes the cellular type I interferon response by blocking phosphorylation of IRF-3, a transcription factor that turns on the expression of a large number of antiviral genes. To identify the domain of VP35 responsible for interferon antagonism, we generated mutations within the VP35 gene and found that a C-terminal basic amino acid...

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