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AIDS/HIV Vaccine

Depo-Provera before SIV challenge eliminates lentivirus-induced protection

Published in Medical Letter on the CDC and FDA, December 19th, 2004

Administration of Depo-Provera before intravaginal challenge with simian immunodeficiency virus mac239 eliminates attenuated lentivirus-induced protection in rhesus macaques.

According to recent research published in the Journal of Infectious Diseases, "In nonhuman primate models of acquired immunodeficiency syndrome, live attenuated lentiviruses provide the most reliable protection from systemic and mucosal challenge with pathogenic simian immunodeficiency virus (SIV). Although live attenuated lentiviruses may never be used in humans because of safety concerns, understanding the nature of the protective immune mechanisms induced by live attenuated vaccines in...

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