AIDS/HIV Vaccine
Non-neutralizing anti-HIV-1 antibody becomes neutralizing antibody
Published in Medical Letter on the CDC and FDA, December 19th, 2004
According to published research from the United States, "During HIV-1 infection or vaccination, HIV-1 envelope spikes elicit antibody responses. Neutralizing antibodies block viral entry by recognizing epitopes on spikes critical for their interaction with receptor, coreceptors or fusion. In contrast, non-neutralizing antibodies fail to do so because they recognize epitopes either buried or exposed but not critical for viral entry."
"Previously, we produced a high-affinity human mAb against the cluster II determinant of...
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