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Hepatitis E Virus

Kyrgyzstan swine hepatitis E virus sequenced

Published in Medical Letter on the CDC and FDA, January 16th, 2005

Scientists have sequenced of a Kyrgyzstan swine hepatitis E virus (HEV) isolated from a piglet thought to be experimentally infected with human HEV.

"Hepatitis E virus (HEV) was identified by RT-PCR amplification with degenerate ORF2 primers in the stool of a piglet experimentally inoculated with a stool suspension from a patient with acute hepatitis during an outbreak of non-A, non-B hepatitis in Kyrgyzstan. Further characterization by sequencing of the complete genome and phylogenetic analysis showed that the piglet isolate was most closely related to HEV genotype 3," investigators in the United States and Kyrgyzstan report.

"Because the original...

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