Rotavirus Vaccine
Mutation of rotavirus genome alters expression of IRF3-interacting protein
Published in Medical Letter on the CDC and FDA, January 23rd, 2005
According to a study from the United States, "Rotavirus, a cause of severe gastroenteritis, contains a segmented double-stranded (ds) RNA genome that replicates using viral mRNAs as templates. The highly conserved 30-consensus sequence (3'CS), UGUGACC, of the mRNAs promotes dsRNA synthesis and enhances translation. We have found that the 3'CS of the gene (g5) encoding NSP1, an antagonist of interferon signaling, undergoes rapid mutation when rhesus rotavirus (RRV) is serially passaged at high multiplicity of infection (MOI) in cells permitting high titer growth."
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