Benzene
Xenobiotic metabolism and mechanism of benzene toxicity reviewed
Published in Medical Letter on the CDC and FDA, January 30th, 2005
"The investigation of the mechanisms of benzene toxicity/leukemogenesis over the past 50 years has been contemporaneous with developments in the study of xenobiotic metabolism. Research on the cytochrome P450 (CYP) enzyme system, and related systems in vivo and in vitro, which culminated in the isolation and reconstitution of the many CYPs, established pathways for the study of xenobiotic metabolism and its relationship to the biological activity of many chemicals. The essential role for metabolism of benzene as a precursor to the...
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