Medical Letter on the CDC & FDA
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Anthrax Vaccine
Protein fusion enhances immunogenicity of anthrax protective antigen
February 20th, 2005
Adaptation of the endogenous Salmonella enterica serovar typhi clyA-encoded hemolysin for antigen export enhances the immunogenicity of anthrax protective antigen domain 4 expressed by the attenuated live-vector vaccine strain CVD 908-htrA. According to a study from the United States, "Bacterial live-vector vaccines aim to deliver foreign antigens to the immune system and induce protective immune responses, and surface-expressed or secreted antigens are generally more immunogenic than cytoplasmic constructs. We hypothesize that an optimum expression system will use an endogenous export system to avoid the need for large amounts of heterologous DNA encoding...
Source: Medical Letter on the CDC & FDA (2005-02-20)
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