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Cardiovascular Research
Results suggest molecular link between cellular injury and inflammatory response
February 20th, 2005
Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2. According to published research from the United States, "Xanthine oxidoreductase (XOR) is the enzyme responsible for the final step in purine degradation resulting in the generation of uric acid...[We]have generated mice deficient in XOR. As expected, these animals lack tissue XOR activity and have low to undetectable serum levels of uric acid." T. Ohtsubo and colleagues of the U.S. National Institutes of Health continued, "Although normal at birth, XOR-/- mice fail to thrive after 10 to 14 days, and most die within the first month. The cause of death appears to be a...
Source: Medical Letter on the CDC & FDA (2005-02-20)
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