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Complementary and Alternative Medicine
Phosphodiesterase-5 inhibitors in dietary supplements analyzed
February 20th, 2005
Researchers have developed a method to analyze undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices using LC-ESI-MS and LC-UV. According to recent research published in the Journal of Pharmaceutical and Biomedical Analysis, "A liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) method was developed to screen for the presence of synthetic phosphodiesterase type 5 (PDE-5) inhibitors including sildenafil, tadalafil, and vardenafil. The method was applied to the analysis of dietary supplements and bulk herbal materials. Bulk powders or composites of tablets, capsules or liquids were prepared and an...
Source: Medical Letter on the CDC & FDA (2005-02-20)
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