Medical Letter on the CDC & FDA
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HIV/AIDS Pathogenesis
Mechanisms for macrophage-mediated HIV-1 induction investigated
February 20th, 2005
Scientists report the results of a study to investigate mechanisms for macrophage-mediated HIV-1 induction in a recent issue of the Journal of Immunology. "Viral latency is a long-term pathogenic condition in patients infected with HIV-1. Low but sustained virus replication in chronically infected cells can be activated by stimulation with proinflammatory cytokines such as TNF-alpha, IL-1 beta, or other host factors. However, the precise mechanism by which cellular activation induces latently infected cells to produce virions has remained unclear," scientists in the United States report. "In the present report, we present evidence that...
Source: Medical Letter on the CDC & FDA (2005-02-20)
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