Medical Letter on the CDC & FDA
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Ebola Virus
Rescue of Ebola virus from cDNA using heterologous support proteins studied
February 20th, 2005
Researchers demonstrate the rescue of Ebola virus from cDNA using heterologous support proteins in a recent issue of Virus Research. According to a study from Canada and the United States, "Using the infectious clone for Zaire Ebola virus, the functional specificity of viral proteins of the ribonucleoprotein complex in transcription/replication was investigated by substituting them with heterologous proteins derived from closely (Reston Ebola virus) and distantly related filoviruses (Marburg virus). The data clearly demonstrated that transcription/replication are neither strictly species-specific nor genus-specific. Protein interactions between the nucleoprotein...
Source: Medical Letter on the CDC & FDA (2005-02-20)
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