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Foot-and-Mouth Disease Vaccine
Method to validate BEI inactivation of foot-and-mouth disease virus
February 20th, 2005
Scientists have developed a method to validate the binary ethyleneimine (BEI) inactivation of foot-and-mouth disease tissue culture vaccine. According to recent research published in the journal Biologicals, "The complete inactivation of Foot-and-Mouth Disease (FMD) virus is a critical requirement in the production of FMD vaccine to ensure the safety of the product. Binary ethyleneimine (BEI) is an aziridine compound, produced from bromoethylamine hydrobromide (BEA) commonly used for the inactivation of FMD virus during vaccine manufacturing. The validation of BEL when used as an inactivant, is essential to ensure the quality of the inactivating agent and the...
Source: Medical Letter on the CDC & FDA (2005-02-20)
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