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HIV/AIDS Risk Factors

DC-SIGN promoter polymorphism increases risk of parenteral HIV-1 infection

Published in Medical Letter on the CDC and FDA, February 20th, 2005

The DC-SIGN promoter polymorphism is associated with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection.

According to recent research from the United States, "There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611...

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