HIV/AIDS Vaccine

Cross-clade CD8 response to HIV-IIIB and Chinese B' and C/B' viruses reported

Published in Medical Letter on the CDC and FDA, February 20th, 2005

Researchers report cross-clade CD8 T-cell responses to HIV-IIIB and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors in a recent issue of the Journal of Acquired Immune Deficiency Syndromes.

"HIV variation presents an obstacle to a global AIDS vaccine. Viral diversity and host variations in MHC expression both affect vaccine responses. Whether CD8 T cells from HIV-infected donors in 1 part of the world cross-recognize isolates from other regions will provide guidance about whether country-specific vaccines are needed. We compared recognition of HIVIIIB and representative B' (Thai B) and recombinant C/B' virus strains endemic in...

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Source: Medical Letter on the CDC and FDA (2005-02-20)

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