Enzymology
Tissue inhibitors of metalloproteinase 2 use RECK to control cell migration
Published in Medical Letter on the CDC and FDA, March 6th, 2005
"The antiangiogenic function of the tissue inhibitors of metalloproteinases (TIMPs) has been attributed to their matrix metalloproteinase inhibitory activity. Here we demonstrate that TIMP-1 but not Ala+TIMP-1 inhibits both basal and vascular endothelial growth factor (VEGF)-stimulated migration of human microvascular endothelial cells (hMVECs), suggesting that this effect is dependent on direct inhibition of matrix metalloproteinase (MMP) activity," scientists in the United States report.
"In contrast, TIMP-2 and mutant Ala+TIMP-2, which is devoid of MMP inhibitory...
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