Published in Medical Letter on the CDC and FDA, March 13th, 2005
According to recent research published in the journal Biologicals, "Yellow fever vaccines are routinely assayed by plaque assay. However, the results of these assays are then converted into mouse LD50 using correlations/conversion factors, which, in many cases, were established many years ago. The minimum required potency in WHO Recommendations is 103 LD50 /dose. Thirteen participants front eight countries participated in a collaborative study whose aim was to assess the suitability of two candidate preparations to serve as an...
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