Tuberculosis Vaccine

DNA vaccine protects mice against primary TB infection

Published in Medical Letter on the CDC and FDA, March 13th, 2005

A polyvalent DNA vaccine expressing an ESAT6-Ag85B fusion protein protects mice against a primary infection with Mycobacterium tuberculosis and boosts BCG-induced protective immunity.

According to a study from the United States, "In this study, we evaluated the protective efficacy of a DNA vaccine (pE6/85) expressing an ESAT6-Ag85B fusion protein against a primary Mycobacterium tuberculosis infection in mice. In short-term studies, vaccination with pE6/85 protected as well as Mycobacterium bovis BCG immunization with similar lung pathology and bacterial burdens detected 28 days after a low dose aerogenic challenge (>1.0 log₁₀ ...

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Source: Medical Letter on the CDC and FDA (2005-03-13)

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