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Varicella-Zoster Vaccine

Genetic profile of Oka varicella vaccine virus variant presented

Published in Medical Letter on the CDC and FDA, March 13th, 2005

Scientists present the genetic profile of an Oka varicella vaccine virus variant isolated from an infant with zoster in a recent issue of the Journal of Clinical Microbiology.

According to published research from Germany and the United States, "Varicella virus vaccine strain Oka (V-Oka) has in rare cases caused zoster in vaccinated people. Despite broad usage of V-Oka, little is known about varicella-zoster virus genomic sequence variation of strains in vaccine and isolates from patients with vaccine adverse events. Direct sequencing of 20 regions of V-Oka-GSK was compared to the sequences of the original V-Oka-Biken, GlaxoSmithKline Oka vaccine (V-Oka-GSK), and...

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