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Medical Letter on the CDC and FDA

Susan Hasty, Publisher

Table of Contents . . . March 20th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications

Childhood Obesity - Parental feeding restriction increases child eating and weight status

Drug Safety - Standard deviation in estimating doses with continuous data clarified

Enzymology - Enzymes found in Mycobacterium vanhaalenii PYR-1

Muscle Regeneration - Chemokine receptor CCR2 involved in skeletal muscle regeneration

Occupational Health - Effect of viewing angle on luminance and contrast for displays compared

Abdominal Aortic Aneurysms - Company applauds the U.S. Preventive Services for recommending AAA screening

Acute Coronary Syndrome Treatment - Heart attack treatment gap may be closing for women

Aesthetic Medicine - Medical laser gets FDA approval for use in liposuction cosmetic surgery

Anthrax Vaccines - Researchers provide details of new studies and findings in the area of anthrax vaccines

Atherosclerosis - Excessive alcohol increases risk of arterial stiffening in men

Autism - U.S. CDC seeks earlier detection of developmental disorder

B-Cell Lymphoma - Flow cytometry useful for detection of occult CSF involvement

Bacteriology - Some Staphylococcus aureus clones more virulent than others

Biomedical Engineering - Patented transdermal technology enables delivery of drugs, vitamins, others

Bioterrorism - Human testing of ricin vaccine - RiVax - begins

Bladder Cancer - Dietary carotenoids and genetic instability modify bladder cancer risk

Breast Cancer - U.S. FDA approves product for digital mammography application

Breastfeeding - American Academy of Pediatrics issues revised policy statement

Business & Finance - Drug-delivery company reports year-end net loss of $37.5 million

Business Update - Bone paste product receives clearance from U.S. FDA

Business Update - FDA accepts ACEON supplemental new drug application for filing

Business Update - Medical device company files with U.S. FDA for clearance of cellulite treatment

Business Update - Medical device company to tackle U.S. market following U.S. FDA clearance

Business Update - Pathway Ureteral Access Device cleared by FDA

Business Update - Reforms will improve oversight and openness at U.S. FDA

Cancer Risk Factors - Obesity associated with progression of prostate and renal cell cancer

Cancer Therapy - FDA accepts Xinlay NDA in treating metastatic hormone-refractory prostate cancer

Cardiology - New findings in cardiology described

Childhood Development - CDC launches "Learn the signs. Act early." campaign

Chromatography - New class of chiral chromatography products to be developed under U.S. NIH grant

Coccidian Parasite -  C. cayetanensis important parasite in immunocompromised persons

Coccidiosis Vaccine - Conserved 19-kDa Eimeria tenella antigen is a profilin-like protein

Coronary Artery Disease - A high percent of CAD/MI population may carry mutations in MEF2A

Cryptococcus - Rare C. gattii genotype cause of cryptococcosis outbreak on Vancouver Island

Diabetes Risk Factors - Dioxin downregulates gene linked to onset of type 2 diabetes

Diabetes Therapy - Recent findings in diabetes therapy provide new insights

Diagnostics - Diagnostic specificity of classical swine fever higher by post-mortem exam only

Diagnostics - Latex agglutination test diagnoses visceral leishmaniasis in HIV co-infection

Diagnostics - San Francisco County first to diagnose TB with QuantiFERON-TB GOLD

Diagnostics - Specimens preserved with dissimilar techniques yield differential data

Diagnostics - Subcutaneous dirofilariasis case caused by Dirofilaria repens

Diagnostics - Test to check for bladder cancer more reliable than cystoscopy, study shows

Diagnotics - PCR-based method accurately detects thalassemia mutations in cord blood

Diet and Nutrition - No adverse effects seen with controlled substitution of soy protein for meat

Disease Transmission - Safer mother-to-child anti-HIV drugs effective, but more expensive

Drug Delivery - U.S. FDA grants clearance for wireless monitoring for infusion pump

Drug Development - Generic drug company announces tentative FDA approval for anitbacterial drug

Embryonic Stem Cell Research - Ethical debates impede progress of embryonic stem cell research

Emergency Medicine - Ruptured gastrointestinal stromal tumor mimics acute appendicitis

Enterococcus Faecalis - Gentamicin-resistant Enterococcus faecalis strains characterized

Environmental Health - Consequences of environmental stress on human health outlined

Environmental Health - Government: Toxic pool has PCB levels 200,000 times above safe

Environmental Health - Researchers publish new studies and findings in the area of environmental health

Environmental Health - Study proposes plastic bag ban in Kenya to eliminate health hazards

Epidemiology - Older HIV+ heterosexual women and MSM in U.K. going undiagnosed

Epidemiology - Water is a major vehicle for Cryptosporidium transmission

Epidemiology - Waterborne transmissions increasing for Toxoplasma gondi

Epilepsy - Cyberonics announces first enrolled patient in E20 VNS epilepsy study

Epilepsy - FDA grants priority review to Keppra for use in childhood epilepsy

Finance - Biopharmaceutical company announces second quarter fiscal 2005 financial results

Finance - Grant to support clinical trials of noninvasive cervical cancer detection device

Finance - NAT maker reports strong financial results for Q4 and full-year 2004

Finance - RiVax maker announces private placement of $3.77M with institutional investors

Gastric Ulcer -  Helicobacter pylori and gastric autoimmunity reviewed

Giardia & Cryptosporidium Infections - Nordic countries incidence estimated for Giardia & Cryptosporidium

Glioma - Drug in trials to treat glioma obtains orphan drug designation in Japan

HIV/AIDS Behavior - Theory-based approach identifies job-seeking behavior of persons with HIV/AIDS

HIV/AIDS Diagnostics - Rapid HIV test is in use by U.S.-based teaching hospitals

HIV/AIDS Diagnostics - Rapid and standard HIV Ab ELISAs negatively affected by HIV-indeterminates

HIV/AIDS Epidemiology - HIV-1 genetically diverse in rural eastern Cameroon

HIV/AIDS Epidemiology - Homeless in San Francisco HIV seroconversion incidence/risk factors estimated

HIV/AIDS Prevention - Antenatal couple counseling prevents HIV-1 transmission

HIV/AIDS Prevention - Antiretrovirals to prevent vertical transmission protects against infant anemia

HIV/AIDS Prevention - HIV prophylaxis should be offered to children following sexual assault

HIV/AIDS Prevention - New collaborations offer hope for HIV/AIDS vaccine

HIV/AIDS Psychology - Stigmatization highest in HIV-infected persons with mental illness

HIV/AIDS Therapy - Data released from study comparing Viread and Emtriva to Combivir

HIV/AIDS Therapy - Large difference in cervicovaginal penetration among antiretroviral agents

HIV/AIDS Treatment - Clinton signs agreement with China to provide AIDS drugs to children

HIV/AIDS Tuberculosis Coinfection - Immune reconstitution syndrome develops within 6 months in HIV/TB coinfection

HIV/AIDS Vaccine - Evolutionary ability of human immunodeficiency virus outlined

Heart Disease Risk Factors - Markers of increased cardiovascular risk evaluated

Heart Disease Therapy - Results of Polish Angina Treatment Pattern study released

Hematology - Adults with hemophilia need screening and treatment for HIV and hepatitis C

Imaging - Phase-sensitive inversion-recovery techniques have a number of benefits

Infectious Disease - Physicians call for increased funding for federal infectious disease programs

Influenza - U.S. health official says mutated bird flu virus could cause worldwide pandemic

Influenza Outbreaks - Global climate variability associated with influenza epidemics

Information Technology - IBM launches software to help exchange of clinical data during medical crises

Information Technology - U.S. FDA compliant product labeling system developed

Injury Prevention - Program helps parents set limits to reduce teens' risky driving

Legal Issues - Vaccine maker announces change in status of SEC inquiry

Leishmaniasis Vaccine - Dendritic cells in Leishmania infection reviewed

Leukemia - Generic drug company, Gamida-Cell to develop StemEx for treatment of leukemia

Locust Plague Monitoring - MODIS data monitors oriental migratory locust plague

Lung Cancer Therapy - Docetaxel approved for treatment of advanced non-small-cell lung cancer

Lyme Disease Vaccine - Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle

Malaria -  Plasmodium parasite is a "new" challenge for insect innate immunity

Malaria - Improved detection and response is useful tool for malaria epidemic planning

Malaria - Recent findings illuminate research in malaria

Malaria Vaccines - Reports advance knowledge in malaria vaccines research

Maternal Mortality - Many maternal deaths go unreported

Medical Devices - Company introduces new defibrillator for professional rescuers

Multiple Sclerosis - Two-year monotherapy trial shows impact on MS disability progress, relapse rate

Neonatology - Research casts further doubt on newborn sex-assignment surgeries

Neurodegeneration - Quercetin protects against oxidative stress-induced neurodegeneration

Non-Hodgkin Lymphoma - Findings in non-hodgkin lymphoma provide new insights

Obesity Pathogenesis - Control of hyperphagia prevents obesity in BDNF heterozygous mice

Occupational Health - Programs to prevent needlestick injuries in healthcare workers launched

Osteomyelitides - Systemic osteomyelitides due to Mycobacterium avium reported

Pain Management - Depomed initiates phase II clinical trial for Gabapentin ER in pain indication

Pain Management - Safer, abuse deterring, long-acting once-daily pain management drug developed

Pain Medicine - Vioxx could rejoin painkillers on market

Patents - Healthcare technology company issued patent for early cancer detection product

Patient Compliance - Fixed-dose combination pills improve patient compliance

Pediatric Healthcare - Afghan officials say at least 180 children have died in winter freeze

Pertussis Vaccines - Research in pertussis vaccines provides new insights

Pneumococcal Vaccines - Researchers publish new studies and findings in the area of pneumococcal vaccines

Poliomyelitis - Health authorities to launch crucial second round of polio immunization

Prenatal HIV Screening - Minority, lower SES women in U.S. tend to express more confidentiality concerns

Prion Disease - Single source of chronic wasting disease unlikely in north-central Colorado deer

Prostate Cancer - Injectable hormonal therapy for advanced prostate cancer available in the U.S.

Psoriasis - FDA approves NDA for treatment of corticosteroid for plaque type psoriasis

Pulmonary Hypertension - ARDS and pulmonary hypertension treated in child with Bordetella

Quality Assurance - Legislation would require Maryland hospitals to publish infection rates

SARS - SARS survivors suffer from increased distress and poor quality of life

SARS Coronavirus - SARS-CoV genome detected in nasopharyngeal aspirate and autopsy lung specimen

SARS Outbreaks - Research in SARS ouTBreaks provides new insights

SARS Vaccine - Core structure from SARS coronavirus S2 fusion protein determined

Schizophrenia Therapy - Initiative to improve cognition in schizophrenia presented

Small Mammal Outbreaks - Small mammals outbreaks influenced by multiple factors

Smoking Cessation - Inpatient counseling is associated with early differences in mortality

Staphylococcus Epidemiology - Methicillin-resistant Staphylococcus in Hong Kong reported

Stem Cell Research - Caspase-3 crucial for osteogenic differentiation of BM stromal stem cells

Streptococcus Vaccine - Invasive group B streptococcal disease in Danish infants reviewed

Stroke - Viagra used in stroke recovery study

Surgical Technology - Quantix/OR blood flow measurement 510k accepted by U.S. FDA

Tuberculosis - Recurrent tuberculosis in US/Canada mostly due to relapse with same strain

Tuberculosis Vaccines - Researchers' data advance tuberculosis vaccines research

Violence - Homicide a leading cause of death among pregnant and postpartum women in U.S.

Water Treatment - Coagulation pretreatment influences protozoan cyst removal from water

Weight Loss - Drugs aid weight loss among type 2 diabetes patients

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