HIV/AIDS Vaccine
HIV-1 virus-like particles are potent immune stimulators
Published in Medical Letter on the CDC and FDA, March 27th, 2005
"Several previous reports have clearly demonstrated the strong effectiveness of human immunodeficiency virus (HIV) Gag polyprotein-based virus-like particles (VLP) to stimulate humoral and cellular immune responses in complete absence of additional adjuvants. Yet, the mechanisms underlying the strong immunogenicity of these particulate antigens are still not very clear," scientists in Germany and Austria report.
"However, current reports strongly indicate that these VLP act as 'danger signals' to trigger the innate immune system...
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