Susan Hasty, Publisher
Table of Contents . . . April 3rd, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Antibiotics - Intent-to-treat and per-protocol results in antibiotic trials compared
Biowarfare - Chlorine inactivation of bacterial bioterrorism agents reported
HIV/AIDS Vaccine - Experiences of men who have sex with men with risk counseling reported
Hepatitis C Virus - Obtaining maximum information about hepatitis C quasispecies discussed
Neisseria Epidemiology - Risk of N. meningitidis high in travelers to Hajj in Saudi Arabia
AIDS Funding - U.S. HHS awards almost $1.7 billion for HIV/AIDS care
AIDS Mortality - U.N.: AIDS may kill 80 million Africans by 2025
Aesthetic Medicine - U.S. FDA clears Ellipse I2PL system for skin rejuvenation
Age-Related Macular Degeneration - FDA completes review of age-related macular degeneration trial protocols
Age-Related Macular Degeneration - New treatment for wet age-related macular degeneration
Alcohol Use - Police alcohol checks put sales to teens on ice
Androstenedione - No hepatotoxicity of androstenedione found in pregnant rats
Anthrax Vaccine - HEPA/vaccine plan for indoor anthrax remediation outlined
Anthrax Vaccine - Mucosal administration of rPA protects against inhalational anthrax
Arsenic Exposure - Eliminating arsenic in drinking water decreased lung cancer mortality in Taiwan
Assisted Reproduction - Suboptimal endometrial lining may thwart ART success in some women
Bacteriology - U.S. FDA grants priority review for antibiotic treatment for skin infections
Black Tea - Black tea intake does not modulate mutagen excretion from ingested beef
Blood Banking - Quality control programs ensures quantity/quality of preserved cord blood
Bovine Arbovirus - Culicoides oxystoma potential vector for bovine arbovirus in southern Japan
Breast Cancer - Neulasta trial results published in The Journal of Clinical Oncology
Breast Cancer - XPD polymorphism increases breast cancer risk from PAH-DNA adducts/cigarettes
Business & Finance - ATryn maker reports "significant progress" in 2004
Business & Finance - Anti-infectives-focused biotech company reports Q4, year end 2004 results
Business & Finance - Medical device firm reports record 4Q, 2004 neuro sales increased 36%
Business Update - FDA issues warning letter to insulin pump maker
Cancer Diagnostics - FDA does not recommend approval of the proposed indication for Combidex
Cancer Research - Pharmaceutical company reports transfer of orphan drug status for oncology drugs
Cancer Risk - Opium smoking associated with elevated carcinoembryonic antigen levels
Cancer Therapy - Alliance established for trial of non-small cell lung cancer vaccine
Cancer Vaccines - New findings in cancer vaccines described
Carcinogens - Carcinogenicity of dioxin-like compound mixture is dose additive
Childhood Immunization - Many children are undervaccinated in their first 2 years of life
Childhood Immunization - Openness is key to winning the war over MMR
Childhood Obesity - Study of obesity and type 2 diabetes in adolescents reported
Clinical Trials - Company to meet with FDA before unblinding of phase III E2F Decoy trial
Clostridium Infection - Patients with C. difficile-related diarrhea have higher mortality
Complementary & Alternative Medicine - Kava ingestion results in altered mental status and ataxia
Cryptosporidium - Cryptosporidium outbreak in Milwaukee, Wisconsin, analyzed
Cryptosporidium Outbreaks - Cryptosporidium outbreaks occur from microbiology standard-compliant water
DPT Vaccine - Diphtheria/pertussis vaccine components should be inactivated toxins
Dementia - Midlife CV risk factors increase risk for late-life dementia
Dengue Virus - Selection for virulent dengue viruses occurs in humans and mosquitoes
Diagnostics - ELISA developed for detection of bromoxynil in water
Diagnostics - FDA grants clearance to market drug screens with acetaminophen
Diet & Nutrition - Food costs, convenience predict obese women's fat intake
Diet & Nutrition - Nutrient content of parental and genetically modified rice compared
Drug Abuse - Study examines consequences of Thailand's "war on drugs"
Drug Development - Aczone demonstrates reduction in number, severity of acne lesions
Drug Development - Enrollment of new patients in trials of alagebrium temporarily suspended
Drug Development - European approval granted for Omnex surgical sealant
Drug Development - FDA grants Fast Track designation for aerosolized Amikacin
Drug Development - FDA grants approvable letter for extended-release Glumetza for diabetes
Drug Development - FDA grants approval for protocol amendment to ARISE phase III trial
Drug Development - Tentative FDA approval for conepezil hydrochloride to Ranbaxy Lab announced
Drug Importation - International drug sales rose 7% last year but pace of growth slowed
Drug Safety - Companies voluntarily suspend Tysabri for multiple sclerosis
Drug Safety - FDA advisory panel discussion points to Aleve
Ebola Virus - Ebola glycoprotein toxicity mediated by dynamin-dependent pathway
Endocrinology - NDA for human insulin-like hormone to treat IGF-1-caused short stature submitted
Environmental Pollution - Carcinogens in house dust can pose potential health risks
Epidemics - Outbreak frequency selection explains frequent infection via pathogen evolution
Epidemics Dynamics - Actual reproduction number adds to understanding of epidemic dynamics
Epidermolysis Bullosa - Next stage of clinical trial for treatment of epidermolysis bullosa underway
Epilepsy - Company launches VNS Therapy system in Korea and Brazil
Epstein-Barr Virus - Real-time Q-PCR distinguishes disease-associated EBV from incidental virus
Euthanasia - Newborn euthanasia often goes unreported in Netherlands
Finance - Drug-delivery company reports full-year 2004 sales growth of 50%
Finance - Pharmaceutical company announces filing of ninth ANDA with U.S.FDA
Finance - Pharmaceutical company completes $25M financing
Finance - Pharmaceutical company reports 2004 4th quarter and year end financial results
Finance - Pharmaceutical company reports fourth quarter results
Food Safety - Antimicrobial solution effective against 'Campylobacter jejuni,' company says
Food-Borne Illness - Norovirus and food-borne disease in the United States reviewed
Food-Borne Pathogen - Active hand washing training increases retention in food preparers
Food-Borne Pathogen - Street vended food poses risk of Salmonella and E. coli infection
Fungi Toxin - Molecular aspects determined for fungi toxin
Gastropathy - Current approaches to prevent NSAID-induced gastropathy outlined
Generic Drugs - FDA gives tentative approval to market donepezil hydrochloride tablets
Genetic Disorders - Company receives nonapprovable letter for panic disorder indication for Lexapro
Genotoxicity - Genotoxicity of ambient outdoor air due to hundreds of identified compounds
Green Tea Extract - Catechin extracts from green tea promotes tumor cell survival pathways
HIV Prevention - Company announces 50% enrollment in phase III HIV prevention trial in Ghana
HIV/AIDS Epidemiology - Steady rise in HIV among heterosexuals seen in the U.K.
HIV/AIDS Prevention - Community-based health-education strategy increases STD awareness in rural India
HIV/AIDS Prevention - Few needle sharers perceive susceptibility of contracting HIV
HIV/AIDS Prevention - HIV/AIDS knowledge increases the likelihood of HIV testing in Uganda
HIV/AIDS Prevention - Studies of the social context of microbicide use to prevent STDs inadequate
HIV/AIDS Risk Behavior - Alcohol use associated with HIV risk behavior among rural adolescents
HIV/AIDS Therapy - Study examines lessons learned at Africa's first public antiretroviral clinic
HIV/AIDS Vaccine - DermaVir is a new topical vaccine for HIV/AIDS
HIV/AIDS Vaccine - HIV genomic RNA sequences in female genital tract and blood reported
HIV/AIDS Vaccine - Innate immunity in experimental SIV infection and vaccination explored
HIV/AIDS Vaccines - Researchers' data advance HIV/AIDS vaccines research
HIV/AIDS-Associated Disorder - Acquired rectal fistula may be sign of HIV infection in children
Hantavirus - Trafficking of Andes and Sin Nombre hantavirus glycoproteins outlined
Hantavirus Vaccine - Viremia delayed in immunized macaques challenged with hantavirus
Healthcare Disparities - Differences in care based on class, not just race
Hemophilia B - Major genes share the control of factor IX antibody expression
Hepatitis C Therapy - FDA approves drug combination as first hepatitis C treatment for HIV patients
Hepatitis C Virus - U.S. FDA approves Pegasys and Copegus as hepatitis C treatment for HIV patients
Home Healthcare - Oregon center seeks participants for federally funded family caregiver program
Human Herpesvirus-8 Infection - Sociological risk factors determined for HHV8 infection in cancer patients
Human Papillomavirus - Subsequent HPV risk in HIV+ women not lowered by natural infection
Hypertension - Blood pressure treatment could cut risk of strokes and heart attacks
Hypertension - U.S. FDA extends PDUFA action date for Nebivolol tablets
Imaging - Measuring cardiac rest periods improves understanding of imaging constraints
Influenza - Healthcare employee vaccination rates could be better
Influenza - Hotline method works to educate public
Influenza - World poorly prepared for next influenza pandemic, scientists warn
Influenza Vaccine - Economic analysis of annual influenza vaccination of children reported
Influenza Vaccine - Epitope analysis for influenza vaccine design reported
Information Technology - IT company, Kyberpass release legally enforceable digital signatures system
Injury Prevention - Severe injuries on the rise among children and adolescents riding motorbikes
Insulin - Long-acting insulin analog developed using albumin fusion technology
Lead Poisoning - Lead isotopic measurements in feces match levels in household dust
Leishmaniasis Vaccine - Leishmania membrane proteins are prophylactic against leishmaniasis
Leishmaniasis Vaccine - Drug-sensitive Leishmania vaccine developed
Leptospirosis Outbreaks - Morbidity/mortality decreased among children pre-exposed to leptospires
Listeria Monocytogenes - Low prevalence of Listeria monocytogenes in humans
Liver Cancer - Researchers detail new studies and findings in the area of liver cancer
Lung Cancer - Physical activity may reduce lung cancer risk among those with high exposure
Lymphoma - Company initiates pivotal trial with FK228 in cutaneous t-cell lymphoma
MMR Vaccine - Policies on MMR vaccinations must balance freedoms and responsibilities
MMR Vaccine - Respiratory delivery of MMR vaccine more immunogenic than injection
Malaria Diagnosis - Nucleic acid sequence amplification better than PCR to quantify malaria
Malaria Infection - Plasmodium protein proteolytically processed during cell invasion
Malaria Vaccine - Plasmodium merozoite surface protein protects against malaria
Malaria Vaccine - Allele specificity of antibody responses against P. falciparum outlined
Malaria Vaccine - Parasite growth rates measured in volunteers challenged with malaria
Malaria Vaccine - Vaccines with DNA and viral vectors possess differential immunogenicity
Malaria Vaccines - Researchers report details of new studies and findings in the area of malaria vaccines
Malignant Gliomas - FDA clears phase I/II recurrent malignant gliomas clinical trial
Measles - WHO: Global measles deaths drop 39%
Measles Epidemiology - Measles virus isolated in Croatia during outbreak characterized
Medical Devices - Company receives U.S. FDA clearance for spinal device
Medical Devices - New easy to use defibrillator introduced
Mental Health - Minnesota researchers find promising results for VNS therapy in bulimia patients
Mergers & Acquisitions - Companies discuss proposed acquisition of IMPAC
Mergers & Acquisitions - DaVita receives second FTC request regarding Gambro acquisition
Metabolic Syndrome - Metabolic syndrome examined in Chinese, Malays, and Asian Indians
Metabolic Syndrome - Short-term very-low-carbohydrate diets improve metabolic abnormalities
Mother-to-Child HIV Transmission - Program evaluation in Bangkok finds factors that hinder women's use of services
Neisseria meningitides - Repetitive-PCR distinguishes N. meningitidis outbreak-related strains
Neonatology - How many lives of newborn babies can we save?
Obesity - Therapeutic targets for obesity-associated diabetes based on inflammation link
Pediatric Vaccines - Cost of child immunization services in urban Bangladesh reported
Personnel - Former U.S. FDA chief counsel Peter Barton Hutt nominated to company board
Pneumococcal Vaccine - Self-reported pneumococcal vaccination validated through local agencies
Pneumococcal Vaccines - Research add new data to pneumococcal vaccines body of knowledge
Polio Vaccine - Dendritic cells and macrophages are productively infected by poliovirus
Polio Vaccine - Immunization schedules affect excretion of polio vaccine strains
Polio Vaccine - Seroprevalence of poliovirus antibody in northern Greece reported
Porcine Epidemic Diarrhea Virus - Competitive blocking ELISA detects porcine epidemic diarrhea virus in feces
Prison Health - Expansion to 1,918-bed Lawton Correctional Facility in Oklahoma announced
Probiotics - Guidelines are important in developing and using probiotics
Product Labeling - Labeling revision for cholesterol-reducing statin approved by U.S. FDA
Prostate Cancer - HPV DNA found in prostate tissue suggests role in prostate cancer
Prostate Cancer - Phase 3 data on satraplatin as chemotherapy for prostate cancer published
Pseudomonas Aeruginosa - Multilocus sequence typing used for genetic analysis of P. aeruginosa
Receptor Studies - Study examined the role of estrogen receptors in hypertrophy
Rotavirus Epidemiology - Epidemiology of rotavirus G-types circulating in Hong Kong is changing
Rotavirus Vaccine - Distribution of rotavirus serotypes has implications for vaccines
SARS - Multiple factors increase risk of developing SARS in health care workers
SARS - Researchers publish new studies and findings in the area of SARS
SARS Coronavirus - SARS coronavirus detected in lungs by RT-PCR following death from SARS
SARS Coronavirus - SARS coronavirus more stable than human coronavirus HcoV-229E in lab conditions
Salmonellosis Outbreak - Salmonellosis outbreak associated with rare phage type of S. enteritidis
Severe Combined Immunodeficiency - Panel recommends some gene therapy limits
Sexual & Reproductive Health - English-speaking Hispanic youth more likely to have sex early
Sexually Transmitted Infection - Exploring sexual networks yields insights into sexually transmitted infections
Smallpox - WHO seeks increase in smallpox vaccines
Smallpox Vaccine - Neutralizing anti-vaccinia antibodies titration method standardized
Smallpox Vaccine - Poxvirus CD8+ T cell determinants aid smallpox vaccine design
Stroke - Premarket notification submitted to U.S. FDA for stroke risk assessment test
Stroke - Research add new data to stroke body of knowledge
Sudden Infant Death Syndrome - Tobacco industry pays scientists to challenge secondhand smoke's health risk
Syphilis - Syphilis rates increasing around the world
Syphilis Epidemic - Syphilis epidemics in U.S. have unforced oscillations every 8-11 years
Toxicology - CDC announces first ever agency-wide research agenda
Transplant Medicine - Japan has first death of heart transplant recipient
Tuberculosis Vaccine - BCG vaccine protects neonatal calves against M. bovis challenge
Tuberculosis Vaccine - Early BCG vaccination elicits adult-like immune response in calves
Tuberculosis Vaccines - New research in the area of tuberculosis vaccines detailed
Umbilical Cord Blood - Cord blood banking regulated in the EU to assure safety/efficacy
Vaccine Development - Ethics of mandatory childhood immunizations discussed
Vaccine Development - Oral vaccination with biodegradable particulates reviewed
Vaccine Development - Tiered pricing of vaccines is not subsidy
Vaccine Efficacy - Shifts in global immunization goals from 1984 to 2004 reviewed
Vaccines Development - Researchers provide details of new studies and findings in the area of vaccines development
Varicella-Zoster Virus - Polymorphisms to distinguish varicella-zoster virus strains evaluated
West Nile Encephalitis Vaccine - Live measles vaccine expressing protects against West Nile encephalitis
Zoonosis - Hepatitis E virus chimeras portray replication in cultured cells
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