HIV/AIDS Epidemiology
Low CCR5Delta32 frequency related to higher susceptibility to HIV-1 infection
Published in Medical Letter on the CDC and FDA, April 17th, 2005
According to a study from Iran, "Host genetic control of HIV infection involves certain polymorphisms of some chemokine receptor genes that are associated with susceptibility and progression of HIV-1 infection.
"Recent data suggest that two important polymorphisms in CCR2 and CCR5 chemokine receptors, CCR5Delta32 and CCR2-64I, prevent HIV transmission and delay disease progression. In this study allele and haplotype frequencies of the CCR5Delta32 and CCR2-64I mutations were determined in southern Iranian normal population using PCR and PCR...
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