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Effect of hypoosmolality on SON magnocellular neuron gene expression clarified

Published in Medical Letter on the CDC and FDA, April 24th, 2005

The effects of hypoosmolality on magnocellular neuron gene expression in the supraoptic nucleus have been clarified.

"Hypoosmolality produces a dramatic inhibition of vasopressin (VP) and oxytocin gene expression" in the SON, endocrinologists in the United States explained.

In their study, N. Mutsuga and coauthors at the National Institute of Neurological Disorders and Stroke examined "the effect of sustained hypoosmolality on global gene expression in the oxytocin and VP magnocellular neurons of the hypothalamo-neurohypophysial system, to identify genes associated with the magnocellular neuron's adaptation to this physiological condition."

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