Published in Medical Letter on the CDC and FDA, April 24th, 2005
Study 1: Intranasal immunization with inactivated SARS-CoV induced local and serum antibodies in mice.
"SARS-CoV (severe acute respiratory syndrome-associated coronavirus) strain GZ50 was partially purified and inactivated with 1:2000 formaldehyde. In cell culture the inactivated virus blocked the replication of live virus by decreasing the TCID5.0 of the live virus 103.6 to 104.6 times. Inactivated GZ50 was used to immunize mice intranasally either alone, or after precipitation with polyethylene glycol (PEG), or with...
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