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Systemic Lupus Erythematosus

Antibody-induced IL-2 deficiency could cause autoantibody production in lupus

Published in Medical Letter on the CDC and FDA, April 24th, 2005

Antibodies present in the serum of patients with systemic lupus erythematosus adversely affect interleukin-2 production, which, in turn, may result in autoantibody production seen in SLE, study findings suggest.

Lupus is a chronic, autoimmune disease that causes inflammation, particularly of the skin, joints, blood, and kidneys. Patients with lupus produce antibodies against their own proteins. Patients also have immune T cells that produce interleukin (IL)-2, which normally usually protects against infection, at lower than typical levels.

In a study in the April 1, 2005, print edition of the Journal of Clinical Investigation, George Tsokos...

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