Pharmaceutical and Drug Development
pH dependence of binding of drugs to plasma proteins in man reviewed
Published in Medical Letter on the CDC and FDA, April 24th, 2005
According to a study from the United States, "An analysis of pH-induced changes of drug binding may contribute to the understanding of the mechanisms involved and the clinical relevance. A literature search was performed, and acceptance criteria set up to select reported data for quantitative evaluation. The relationship between percentage of unbound drug, fraction unbound (fu), and pH was analyzed, and the relevance of physicochemical characteristics of the ligand drugs and the importance of hydrogen ion-induced changes in plasma...
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