Drug Development
Humanized immunoenzyme targets B-cell lymphoma
Published in Medical Letter on the CDC and FDA, April 24th, 2005
According to scientists writing in the British Journal of Haematology, "we report on the generation and functional characterization of a humanized immunoenzyme comprising a stable humanized single chain Fv (scFv) with grafted specificity of the anti-CD22 murine monoclonal antibody RFB4 and the human ribonuclease angiogenin (ANG)."
"The fusion protein produced from transiently transfected mammalian Chinese hamster ovary cells could easily be purified to homogeneity, retained full ribonucleolytic activity, and efficiently killed CD22+ tumor cells with an IC50 of 56 nmol/l. In contrast,...
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