Susan Hasty, Publisher
Table of Contents . . . May 1st, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Antibiotics - Education increases approval of appropriate antibiotic prescription
Flavivirus - Topology in flavivirus stem-loop determines RNA replication competence
HIV/AIDS Transmission - Condom use and perceived risk of HIV transmission investigated
Influenza Virus - Rapid strategy to characterize influenza B reassortants developed
Pacemakers - Security system simulator to test pacemaker compatibility developed
Adenovirus - Five new adenovirus type 37 strains caused epidemic keratoconjunctivitis
Adverse Drug Reaction - Agency issues final risk minimization guidances
Advocacy - Consumer advocacy group submits Citizen Petition to FDA
Alcohol Use - Alcoholism reduces male heart's ability to synthesize protein
Allergy Medicine - FDA approves ASMANEX (mometasone furoate) for once-daily management of asthma
Angiology - Invasive MRI is feasible and apparently safe during peripheral angioplasty
HIV/AIDS Vaccines - Researchers describe findings in HIV/AIDS vaccines studies
Angiology - U.S. FDA clears Trellis-8 catheter
Antibacterial Agents - Study: E. Coli bacteria remains an important threat to U.S. health
Arthritis - Ulmus davidiana extract suppresses collagen-induced arthritis
Arthritis Pathogenesis - Plasminogen activator system needed for joint inflammation of arthritis
Asthma - FDA publishes final rule on chlorofluorocarbons in metered-dose inhalers
Asthma Pathogenesis - Immunoglobulin-free light chains elicit allergic asthma
SARS - Researchers' data advance SARS research
Atrial Fibrillation - FDA approves Arctic Front IDE for the treatment of atrial fibrillation
Behavioral Health - Lexapro not approved for social anxiety disorder indication
Biochemistry - Study investigated the lifetimes of fluorescent components of matrix NADH
Biotechnology - Lipopolysaccharides removed from protein-lipopolysaccharide complexes
Breast Cancer - MTHFR 677T variant/low folate associated with increased risk of breast cancer
Breast Cancer Risk Factors - CHEK2 1100delC allele frequency is low in breast cancer families
SARS - Studies add new findings to SARS body of knowledge
Breastfeeding - Alcohol consumption disrupts breastfeeding hormones
Business Update - Biopharma files NDA for Enhanze SC
Business Update - FDA approves AcrySof ReSTOR intraocular lens
Business Update - FDA clears heparin-coated cardiopulmonary bypass blood reservoir
Business Update - Immunology-focused biotechnology company updates clinical development plans
Business Update - SinusPharma changes name to reflect focus on chronic rhinosinusisitis treatments
Business Update - Therapeutics co. enters comarketing, supply agreement for therapeutic apheresis
COX-2 - Market research firm predicts prescribing gains for pain drugs
Cancer Research - Therapeutics company offers regulatory update on Cerepro and Vitor
Cardiovascular Disease - Energy intake reduction crucial for weight loss in metabolic syndrome
Cervical Cancer - Killer cell immunoglobulin-like receptor population affects disease risk
Chemotherapy - Epoetin alfa for treatment of cancer-related anemia reviewed
Colorectal Cancer - Abnormal p53 increases risk of death in colorectal cancer
Colorectal Cancer - Beta-catenin and APOE SNPs associated with positive family history of cancer
Congestive Heart Failure - Heart assist device company files for CE Mark approval to market LVAS in Europe
Cord Blood Research - Legislation introduced to create inventory of cord blood stem cell units
Coronary Artery Disease - Increasing BMI improves outcome of stenting for coronary artery disease
Credentialing - Credentials certification deadline nears for NAFTA healthcare professionals
Cryptosporidium Diagnostics - Immunomagnetic separation-PCR discriminates C. parvum and C. hominis
Cystic Fibrosis - Biopharma company granted U.S. FDA fast track status for PTC124
Dengue Virus - New data illuminates research in dengue virus
Dermatology - FDA panels urged to maintain dermatologic corticosteroids as prescription drugs
Dermatology - Safety and efficacy of topical retinoids reviewed
Dermatology - U.S. FDA grants market approval of Fraxel laser for skin resurfacing
Diabetes Therapy - Exubera for treatment of type 1 and type 2 diabetes reviewed
Diagnostics - Blood glucose monitoring system gets FDA approval for alternate site testing
Diagnostics - DHPLC superior to SSCP in screening p53 mutations in esophageal cancer tissues
Diagnostics - FDA grants 510(k) clearance for imaging display system
Diagnostics - U.S. FDA clears Hycor Biomedical autoimmune test for diagnosing celiac disease
Diet & Nutrition - FDA's new rules provide reminder of fish benefits, risks, especially for women
Diet & Nutrition - Methods to determine relation between food and disease risk outlined
Drug Abuse - New findings could change the face of drug addiction treatment
Drug Development - Status of NDA for Tramadol ER updated
Endometriosis - FDA approves depo-subQ provera 104 for management of endometriosis pain
Enterobacter - Enterobacter cloacae outbreak strain produced VEB-3 beta-lactamase
Environmental Health - DuPont reduces environmental footprint
Environmental Health - Endosulfan and metabolites in plasma and selected tissues analyzed
Environmental Health - Parents fail to set rules to limit children's exposure to tobacco smoke
Fascioliasis - ELISA developed to diagnosis human fascioliasis
Finance - Biopharma company announces net loss of $0.10 per share for the year
Finance - Gastro-focused pharmaceutical company reports Q4, full year 2004 results
Finance - German-American biotech company reports financial results
Finance - Imaging company completes $10.5 million private placement transaction
Finance - NIH grant will further metabolomics research
Finance - Photoselective medicine company announces financial results
Food-Borne Illness - E. coli O157:H7 in apple juice inactivated by electric fields
Generic Drugs - Tentative approval granted for Levofloxacin Ophthalmic Solution
Genetics & Genomics - Company applauds new FDA guidance for pharmacogenomics
Genetics & Genomics - Study investigated proximate downstream effectors of Notch signaling
HIV/AIDS & Malaria Coinfection - Female adolescents in subSaharan Africa need care for HIV and malaria
HIV/AIDS & Nutrition - Poor nutrition adds to immune degradation in HIV-infected children
HIV/AIDS Pathogenesis - T cell activation in HIV infection higher in Uganda than Western countries
HIV/AIDS Prevention - HIV/AIDS treatment and prevention require a balanced approach
HIV/AIDS Prevention - Physical intimate partner violence does not lead to sexual HIV risk
HIV/AIDS Research - Pharma company submits two new filings of antiretrovirals to WHO
HIV/AIDS Therapy - Atazanavir, once-daily protease inhibitor, reviewed
HIV/AIDS Transmission - Nevirapine is safe, effective, shows new analysis of HIVNET 012 data
HIV/AIDS Tuberculosis Coinfection - PCR useful when microbiological M. tuberculosis diagnosis inconclusive
HIV/AIDS Vaccines - New data illuminates research in HIV/AIDS vaccines
Healthcare Coverage - Urban neighborhoods affect how people think about health
Healthcare Disparity - Health center expansion eliminates health differences
Heart Devices - FDA approves 2000 FlowMaker pivotal trial
Heparin - Approaches to diagnosis of heparin-induced thrombocytopenia reviewed
Hypertension - Increased superoxide anion contributes to hypertension
Imaging - U.S. FDA issues approvable letter for Combidex
Immunology - Long-term spaceflight affects immunoglobulin heavy chains
Immunology - Novel variant of acyl-CoA synthetase isoform 6 identified
Influenza - Complete genome of influenza H5N1 viral isolates from Thailand characterized
Influenza - Priority groups received majority of 2004-05 influenza vaccine
Influenza - Social stress boosts immune system's flu-fighting abilities
Injury Prevention - Golf-related head injuries in children increasing along with sport's popularity
Irritable Bowel Syndrome - 5-HT3 receptor antagonist for irritable bowel syndrome developed
Leukemia Vaccine - Multidrug resistance of leukemia cells decreases tumorigenicity
Listeria Monocytogenes - L. monocytogenes type 2 outcompetes lineage 1 strains
Malaria - African immigrants living in France have long-term malarial immunity
Malaria Vaccines - Researchers report details of new studies and findings in the area of malaria vaccines
Measles Vaccine - Passive immunity to measles found in breast milk and cord blood of Nigerians
Medical Devices - FDA approval granted for new ECG technology
Medical Devices - U.S. FDA grants clearance for treatment table with 550-pound load capacity
Meningitis Vaccine - Bacterial meningitis vaccination program needed in rural Papua New Guinea
Meningococcal Disease - PorA protein relatively stable during meningococcal disease epidemic
Meningococcal Disease - Sequence variation in meningococci porB gene cause of New Zealand epidemic
Methicillin-Resistance Staphylococcus Aureus - Surgical-site MRSA infections began by healthcare worker with chronic sinusitis
Morbidity & Mortality - WHO report calls for new approach to save lives of mothers and children
Mycobacteria - Non-MTB mycobacteria not present in erythema induratum/nodular vasculitis
Mycobacterium Tuberculosis - Fast/simple flow cytometry determines M. tuberculosis susceptibility
Mycobacterium Tuberculosis - MTB Ag 85B phagosomal processing modulated independently of viability/maturation
Mycology - Saccharomyces uvarum (Beijerinck) reinstated as distinct species
Mycology - Cycle time effect on fungal morphology during carbon addition studied
Myeloma - Association applauds VELCADE approval
Myeloma - U.S. DOD awards $1.6 million contract to develop bone-targeting nanocapsules
Myocardial Infarction - Differential heart attack risks among blacks, whites remain mystery
Narcolepsy Therapy - Sodium oxybate for treatment of narcolepsy reviewed
Nicotine Addiction - Consumers not getting accurate information about smokeless tobacco
Nicotine Addiction - Youth tobacco use does not decline significantly from 2002-2004
Obstetrics - Maternal iron deficiency disrupts mother/child interaction
Obstetrics - Researchers' findings advance obstetrics research
Oncogenesis - Green tea extract modulates actin remodeling via Rho activity
Oncology - Recent findings in oncology described
Ophthalmology - New corrective eye surgery system to be distributed in Asia
Ophthalmology - U.S. FDA approves ReZoom multifocal refractive lens
Osteoarthritis - Study compares Lidoderm patch and Celebrex in treating knee
Osteoporosis - FDA approves new Fosamax formulation containing vitamin D
Osteoporosis - FDA approves once-monthly Boniva for osteoporosis
Ovarian Cancer - U.S. FDA accepts IND for treatment of advanced ovarian cancer with MORAb-003
Pathogenic Escherichia Coli - E. coli O157:H7 isolates causing hemolytic uremic syndrome characterized
Pediatrics - FDA approves ZOFRAN for use in children as young as 1 month of age
Pediatrics - Nine-month health visit reformatted to enhance developmental concerns
Pediatrics - Pediatricians must confront community-based threats to health
Personnel - Keith Yamamoto, PhD, appointed to chair of scientific advisory board
Philanthropy - Imaging company donates airway intubation system to Army Hospital in Iraq
Polio Vaccines - Researchers' data advance polio vaccines research
Psoriasis Therapy - Alefacept is a biologic for treatment of psoriasis
Pulmonary Medicine - Mitochondrial DNA damage triggers apoptosis in lung endothelial cells
Quality Assurance - New web site offers hospital performance data
Rabies - Predicted incidence of ruminant neurological disorders vary with species/area
Ralstonia Outbreak - Ralstonia mannitolilytica outbreak strains molecularly characterized
Receptor Studies - Urokinase receptor binding regulates alpha5beta 1 integrin function
Renal Transplantation - Flow cytometric reactive antibody in renal transplant patients examined
Reproductive Health - WHO releases new online Reproductive Health Library
Reproductive Medicine - Study of cows' ovarian follicles may advance human fertility treatments
SARS - Findings advance knowledge in SARS research
SARS - Hospital Emergency Incident Command System implemented during SARS outbreak
SARS Coronavirus - Studies describe new findings in SARS coronavirus research
SARS Vaccines - New research in the area of SARS vaccines detailed
SARS Virus - Thermodynamics and kinetics of SARS virus glycoprotein folding investigated
Septicemia - New formulation of MethLock wins FDA approval for clinical trial
Sexual & Reproductive Health - Teens believe oral sex is safer, more acceptable to peers
Shaken Baby Syndrome - Education program reduces incidents of shaken baby syndrome
Sickle Cell Disease - Management of sickle cell disease reviewed
Sleep Disorders - Insomnia in elderly linked to risk of falls
Smoking Cessation - 75% who quit smoking with smokeless still smoke-free 7 years later
Spinal Stenosis - U.S. FDA IDE conditional approval granted for arthroplasty device
Stem Cell Research - Engraftment of transplanted mice with hematopoietic stem cells reported
Stem Cell Transplantation - Web-based system developed for QOL/symptom self-assessment after HSCT
Stomach Cancer Risk Factors - Stomach cancer risk not associated with exposure to radon or other radionuclides
Systemic Lupus Erythematosus - Infection with Epstein-Barr virus may increase SLE risk in African Americans
Transplant Medicine - Solution for perfusion and flushing of donor pancreata given U.S. FDA approval
Tuberculosis - Control of tuberculosis in Colombia reviewed
Tuberculosis - Gatifloxacin does not kill M. tuberculosis during stationary growth phase
Tuberculosis - Local characteristics of TB clustering identified via molecular fingerprinting
Tuberculosis Vaccines - Reports describe recent advances in tuberculosis vaccines research
Type 2 Diabetes - Lay perceptions of type 2 diabetes in Scotland outlined
Ulcerative Colitis - Drug development company reports on Nuvion meeting with U.S. FDA
Vascular Graft - FDA approves device to treat descending thoracic aneurysms
Virology - Papillomavirus-based transfection necessitates capsid maturation
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