Published in Medical Letter on the CDC and FDA, May 1st, 2005
"Heparin-induced thrombocytopenia (HIT) is a clinicopathologic syndrome that is most reliably diagnosed when a patient with a clinical scenario that is consistent with heparin-induced immunization is shown to have antiplatelet factor 4/heparin, platelet-activating IgG antibodies. A Bayesian diagnostic approach is discussed, wherein the physician estimates the pretest probability of HIT (e.g., the timing and severity of thrombocytopenia in relation to heparin treatment and associated thrombosis) and determines the post-test probability...
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