Human Papillomavirus

Down-regulation of p21 contributes to apoptosis induced by HPV E6

Published in Medical Letter on the CDC and FDA, May 8th, 2005

Down-regulation of p21 contributes to apoptosis induced by HPV E6 in human mammary epithelial cells.

"Infection with human papillomaviruses (HPV) is strongly associated with the development of cervical cancer. The HPV E6 gene is essential for the oncogenic potential of HPV. E6 induces cell proliferation and apoptosis in cervical cancer precursor lesions and in cultured cells. Although induction of telomerase and inactivation of the tumor suppressor p53 play important roles for E6 to promote cell growth, the molecular basis of E6- induced apoptosis is poorly understood. While it is expected that inactivation of p53 by E6 should lead to a reduction in cellular apoptosis,...

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Source: Medical Letter on the CDC and FDA (2005-05-08)

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