Mumps Virus
Rat-based neurovirulence test for mumps virus assessed
Published in Medical Letter on the CDC and FDA, May 8th, 2005
According to recent research from the United States and England, "Because of the highly neurotropic and neurovirulent properties of wild-type mumps viruses, most national regulatory organizations require neurovirulence testing of virus seeds used in the production of mumps vaccines. Such testing has historically been performed in monkeys; however, some data suggest that testing in monkeys does not necessarily discriminate among the relative neurovirulent risks of mumps virus strains."
"To address this problem, a...
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