Malaria Therapy

Molecular models advance the fight against malaria

Published in Medical Letter on the CDC and FDA, May 22nd, 2005

Research from Dartmouth Medical School, demonstrating how malaria parasites form mutations that make them stubbornly resistant to drug therapy, may hold the key to a new treatments for a disease that afflicts more than half a billion people worldwide.

The scientists developed disease models using yeast and successfully introduced five mutations that make malaria resistant to the antimalarial drug atovaquone. The study, featured in Journal of Biological Chemistry, paves the way for using these models to test new drugs that could suppress malaria's ability to mutate against current therapy.

"This is the first quantitative explanation for...

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Source: Medical Letter on the CDC and FDA (2005-05-22)

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