Adenocarcinoma
Secondhand smoke induces adenocarcinoma via p16//DAPK/RASSFIA gene inactivation
Published in Medical Letter on the CDC and FDA, June 5th, 2005
"The prevalence of methylation of the p16, DAPK and RASSFIA genes was investigated in lung adenocarcinoma from smokers, former uranium miners and never smokers. The association between a common genetic alteration in adenocarcinoma, mutation of the K-ras gene and methylation of these genes, as well as survival was examined.
"Adenocarcinomas from 157 smokers, 46 never smokers and 34 former uranium miners were evaluated for methylation of the p16, DAPK and RASSFIA genes using the methylation-specific PCR assay. Comparisons were also made to prevalences...
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