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Cardiology

Demonstration of cardiac myocyte differentiation challenges common view

Published in Medical Letter on the CDC and FDA, June 12th, 2005

Adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro.

Investigators in the United States report, "It has long been held as scientific fact that soon after birth, cardiomyocytes cease dividing, thus explaining the limited restoration of cardiac function after a heart attack. Recent demonstrations of cardiac myocyte differentiation observed in vitro or after in vivo transplantation of adult stem cells from blood, fat, skeletal muscle, or heart have challenged this view."

S.O. Winitsky and colleagues of the U.S. National Institutes of Health continued, "Analysis of these studies has been complicated by...

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