Medical Letter on the CDC and FDA

Anthrax Therapy - Management of anthrax meningitis reviewed

Heart Disease Risk Factors - Moderate drinking may not reduce cardiovascular disease risk

Human Papillomavirus - Factors linked to cervical cancer in HPV-16-positive women reported

Obesity Therapy - Diet and physical activity surveyed among Americans trying to lose weight

Obstetrics - Pregnancy-related mortality in United States assessed

Addiction Medicine - Over 4% of pregnant women used illicit drugs in past month

Adverse Drug Reaction - The Research on Adverse Drug Events and Reports (RADAR) project

Air Pollution - Air pollutants associated with early mortality

Alcohol Use - Students who get drunk weekly have higher risk of injuries

Amyotrophic Lateral Sclerosis - Company files IND application for arimoclomol to treat ALS

Anthrax Vaccines - Reports advance knowledge in anthrax vaccines research

Pneumococcal Vaccines - New findings in the area of pneumococcal vaccines described

Anti-infectives - Tribendimidine is promising, broad-spectrum anti-helmintic agent

Arthritis Therapy - Flurbiprofen preparation improves bioavailability

Asthma - Navy women have higher incidence of first hospitalization for asthma than men

Baculovirus Vaccine - SARS coronavirus protein possesses interesting structure

Bone Marrow Transplant - High autopsy rates maintained in Canadian blood and marrow transplant program

Breast Cancer - Diagnostics company updates NMP66 protein program for breast cancer detection

Breast Cancer - Home-based intervention increases survivors' physical activity

Breast Implants - Fungal contamination of saline-filled breast implants is rare, preventable

Business & Finance - Buccal drug-delivery company gets more time to comply with NASDAQ requirement

Business Update - FDA accepts Hylenex NDA

Business Update - FDA approves 12-month shelf life for Taxus stent system

Business Update - Imaging company's registration statement declared effective

Business Update - U.S. FDA requests additional information on VelaSmooth 510(k) submission

Campylobacter Diagnosis -  Campylobacter coli and C. jejuni identified by PCR

Campylobacter Jejuni - Long-term clonal lineages within C. jejuni O:2 strains from different areas

Cancer Epidemiology - Cancer is major cause of childhood death in developing countries

Cancer Vaccines - Human anti-globulin antibody responses to antibodies reviewed

Carcinogenesis - Carcinogen-DNA adducts formed in mammary cells treated with benzopyrene

Carcinogenesis - Transcriptional signatures of benzo[a]pyrene in mammary cells reported

Cardiology - Medical device company launches 3 cardiology products at EuroPCR 2005 meeting

Chagas Disease - Studies add new findings to Chagas disease body of knowledge

Chemotherapy-Induced Anemia - Data: Aranesp dosed every 2 weeks is comparable to Epoetin alfa dosed weekly

Childhood Obesity - Prevalence of obesity in children in Istanbul reported

Chronic Lymphocytic Leukemia - FDA clears CLL trials for inhibitor drug GRN163L

Chronic Tuberculosis - Chronic TB pulmonary Th1 cell maintenance requires persistent IL-12 production

Clinical Trials - Trial in older cancer patients suggests benefits of drug plus chemotherapy

Collaborations - Commercial supply agreement signed for active drug in AzaSite

Collaborations - Company is first to perform HBV screening using U.S. FDA-licensed protocol

Congestive Heart Failure - Telemonitoring or telephone calls prevent heart failure deaths

Coronavirus Outbreaks - Human coronavirus OC43 caused influenza-like illness in aged-care facilities

Dengue Fever - Dengue virus vaccine induces broad protective antibody response

Dengue Fever - Early T-cell responses to dengue virus epitopes described

Depression - Little change in suicidal thoughts, plans or attempts in U.S.

Dermatology - FDA approves MERREM I.V. for complicated skin and skin structure infections

Diabetes - U.S. FDA grants clearance for expanded indication of wound treatment device

Diabetes Pathogenesis - Data advance knowledge in diabetes pathogenesis research

Diagnostics - FDA advisory panel meeting for AlzheimAlert kit PMA application expected in July

Diagnostics - Method to measure perfluorooctanoic acid by LC-MS/MS developed

Diet & Nutrition - Adolescent girls skip breakfast more often as they grow older

Diet and Nutrition - Dietary vitamin K1 intake may be unrelated to premature coronary calcification

Diet and Nutrition - Stress, anxiety, fatigue influence women's food choices during pregnancy

Diet and Nutrition - Vitamin C modulates T cells only during T cell activation

Disease Outbreaks - Europe still lacks epidemiological field forces to quickly diagnose outbreaks

Drug Abuse - U.S. FDA warns against abuse of dextromethorphan

Drug Delivery - Company expands line with new technologies for biocompatible device coatings

Drug Delivery - Preclinical results with transdermal drug technology announced

Drug Development - Generic Demulen oral contraceptive tablets approved by U.S. FDA

Drug Development - Not approvable letter issued from U.S. FDA for Zimycan

Drug Development - Researchers' data advance drug development research

Drug Development - U.S. FDA grants approvable letter for Retaane suspension

Drug Development - U.S. FDA grants approval on 600 and 800 mg gabapentin tablets

Drug Development - U.S. FDA grants orphan drug designation for cardiogenic shock drug

Drug Resistance - Nevirapine resistance may be higher than previously thought

Drug Safety - Crestor safe, effective when used according to prescribing information

Encephalitis Vaccine - Cytokine-encoding plasmid delivery improves immune response

Environmental Health - Dioxins alter weight by decreasing insulin-like growth factor signaling

Environmental Health - Fungal biotransformation of benzo-quinolines reported

Environmental Health - Healthcare use, work productivity linked to health levels

Environmental Health - Workers exposed to vermiculite have high rate of chest wall abnormalities

Ethics - International medical journal editors call for drug trial registration

Ethics - Medical whistleblowers speak out

Finance - Company is awarded NIEHS grant in toxicogenomics

Food Safety - Hygromycin B phosphotransferase expressed in E. coli

Food-Borne Illness - Information on risks of eating saltwater fish needs broader audience

Food-Borne Outbreak Epidemiology - Questionnaire investigates food-borne disease outbreak in early 20th century

HIV/AIDS Diagnosis - Gay men with late HIV diagnosis have increased short-term mortality

HIV/AIDS Epidemiology - Complex structure of HIV-1 transmission within risk groups revealed

HIV/AIDS Epidemiology - Heterosexual route most common means of HIV transmission in Central India

HIV/AIDS HAART - Nursing guidelines detailed for enfuvirtide management in HIV-infected patients

HIV/AIDS Mental Health - HIV status disclosure yields greater self-esteem and lower depression

HIV/AIDS Pathogenesis - Memory CD4+ T cells decline in multiple tissues during SIV infection

HIV/AIDS Prevention - Alcohol use and victimization predicts high risk sex in cohabiting adults

HIV/AIDS Prevention - Culturally based model designed to reduce Latino adolescent HIV sexual risk

HIV/AIDS Prevention - Differences in risk behavior and perception between U.S. and Russian IVDUs

HIV/AIDS Prevention - Education used to prevent the spread of HIV infection

HIV/AIDS Prevention - Vaginal microbicides can reduce the risk of acquiring HIV in female sex workers

HIV/AIDS Risk Behavior - Crystal methamphetamine use leads to high-risk sex in gay men

HIV/AIDS Testing - HIV voluntary counseling and testing center efficiency lacking in Andhra Pradesh

HIV/AIDS Therapy - FDA committee recommends accelerated approval for Tipranavir

HIV/AIDS Therapy - U.S. FDA approval granted for once-daily Kaletra (lopinavir/ritonavir)

HIV/AIDS Vaccine - Company obtains HIV vaccine license from NIH

HIV/AIDS Vaccine - Detection of HIV gag- and pol-CD8/A2 help monitor vaccine efficacy

HIV/AIDS Vaccine - HIV-mediated cell fusion differentially inhibited by C34 peptides

HIV/AIDS Vaccines - Researchers publish new studies and findings in the area of HIV/AIDS vaccines

HIV/AIDS-Associated Kaposi Sarcoma - Generic HAART reduces viral load to undetectable in AIDS-associated KS patients

HIV/AIDS-Associated Pneumococcal Infection - Elevated procalcitonin/CRP predictive of pneumococcal infection in HIV patients

HIV/AIDS-Associated Pneumonia - IVDU fueling recurrent bacterial pneumonia in people with AIDS in Europe

Hantavirus - Hantavirus epidemics are cyclical